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KMID : 1130620100060040167
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Journal of Clinical Neurology
2010 Volume.6 No. 4 p.167 ~ p.182
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Deep Brain Stimulation: Technology at the Cutting Edge
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Shah Rahul S.
Chang Su-Youne
Min Hoon-Ki
Cho Zang-Hee
Blaha Charles D.
Lee Kendall H.
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Abstract
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Deep brain stimulation (DBS) surgery has been performed in over 75,000 people worldwide, and has been shown to be an effective treatment for Parkinson’s disease, tremor, dystonia, epilepsy, depression, Tourette’s syndrome, and obsessive compulsive disorder. We review current and em-erging evidence for the role of DBS in the management of a range of neurological and psychiatric conditions, and discuss the technical and practical aspects of performing DBS surgery. In the future, evolution of DBS technology may depend on several key areas, including better scientific understanding of its underlying mechanism of action, advances in high-spatial resolution imaging and development of novel electrophysiological and neurotransmitter microsensor systems. Such de-velopments could form the basis of an intelligent closed-loop DBS system with feedback-guided neuromodulation to optimize both electrode placement and therapeutic efficacy.
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KEYWORD
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deep brain stimulation, Parkinson’s disease, mechanism of action
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